Supplemental Figure S1.

Substrate utilization is altered in mice injected with AZD8055. Overnight fasted mice were intraperitoneal-injected with vehicle or AZD8055 (10 mg kg⁻¹); or vehicle or rapamycin (4 mg kg⁻¹) before re-feeding was initiated. (a,c) Carbohydrate (CHO) and (b,d) fat utilizations were calculated based on the respiratory exchange ratio (Figure 1) throughout 6 h of re-feeding (n = 3–4). **p < 0.01 and *p < 0.05 different from vehicle. Data are means ± SEM.