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AZD8055, but not rapamycin, reduces muscle glucose uptake ex vivo. (A,B) Mouse soleus and EDL muscles were incubated ex vivo in the presence of 0.1% DMSO, 640 nM AZD8055 or 1 μM rapamycin for 30 min, followed by basal or insulin (60 nM) stimulation. Glucose uptake was measured with 3H-2-deoxyglucose (n = 7–8). *p < 0.05 different from corresponding DMSO. Data are means ± SEM.
