Table 1.

Baseline and Outcome Diabetic Macular Edema Definitions in Time Domain Optical Coherence Tomography Images

Follow up Macular Edema Categories	Definition
Baseline DME Categories
A. No central involved DME and no non-central involved DME	CSF<190¦ for women or CSF<210¦ for men, and all ISF<260‡, and all OSF<220¶
B. No central involved DME and definite or possible if non-central involved DME	CSF <190¦ for women or CSF<210¦ for men, and at least 1 ISF >260‡ or OSF>220¶
C. possible if central involved DME and no non-central involved DME	CSF 190¦ to 249¦¦ for women or CSF 210¦ to 249¦¦ for men, and all ISF <260‡, and all OSF<220¶
D. Possible if central involved DME and definite or possible if non-central involved DME	CSF 190¦ to 249¦¦ for women or CSF 210 to 249¦¦ for men, and at least 1 ISF >260‡ or OSF>220¶
Central-Involved Macular Edema at Follow Up	Study eye meeting any one of the following: CSF thickness ≥250* μ at 16 weeks and increased at least 1 logOCT unit from baseline to 16 weeks CSF thickness increased at least 2 logOCT units from baseline to 16 weeks Any treatment for DME or CME other than topical medications was received after surgery, and criterion (1) or (2) was met prior to starting treatment
Development or Progression of Non-central- Involved Macular Edema at Follow Up	Study eye meeting any one of the following: At least 1 ISF ≥310† microns at 16 weeks and the corresponding ISF increased at least 1 log unit from baseline to 16 weeks OR at least 1 OSF ≥290†† microns at 16 weeks and the corresponding OSF increased at least 1 logOCT unit from baseline to 16 weeks At least 1 ISF increased at least 2 logOCT units from baseline to 16 weeks OR at least 1 OSF increased at least 2 logOCT units from baseline to 16 weeks Any treatment for DME or CME other than topical drops was received after surgery, and criterion (1) or (2) was met prior to starting treatment

DME=diabetic macular edema; CSF=central subfield; ISF=inner subfields; OSF=outer subfields;; CME=cystoids macular edema

^*310 on spectral domain machines

^†356, 369, and 348 on the spectral domain machines Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue respectively. Values represent mean+2 standard deviations from a normal cohort of the ISFs of respective machines.

^††303, 322, and 307 on the spectral domain machines Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue respectively. Values represent mean+2 standard deviations of the OSFs of respective machines.

^¦Women: 250, 260, and 240; Men: 260, 280, and 240 on the spectral domain machines Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue respectively.

^¦¦309 on the on the spectral domain machines Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue

^‡260, 260, 340 on the spectral domain machines Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue respectively.

^¶260, 220, and 290 on the spectral domain machines Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue respectively.