Table 3.

Frequency of Macular Edema at 16 Weeks

	Definite Central-involved Macular Edema at 16 Weeks
	Proportion (%)	95% Confidence Interval of Proportion
	N = 261
Baseline OCT Thickness
A. No central-involved DME & No non-central  involved DME*	0/17 (0%)	0-20%
B. No central-involved DME & Definite/ possible non -  central involved DME*	10/97 (10%)	5-18%
C. Possible central-involved DME and  Definite/possible non-central involved DME*	18/147 (12%)	7-19%
Baseline OCT Thickness and History of DME Treatment
A. No DME**	0/17 (0%)	0-20%
B. Any DME And No History of DME Treatment	6/140 (4%)	2-9%
C. Any DME With History of DME Treatment	22/104 (21%)	14-30%
Recent DME Treatment Only	0/4 (0%)
Recent and Old DME Treatment	6/18 (33%)
Old DME Treatment Only	16/82 (20%)

CI=central-involved; DME=diabetic macular edema

^*Five eyes, originally classified in the possible central-involved DME and no non-central involved DME group, were individually examined by the protocol chair due to small numbers in the subgroup and were reclassified into the no central or non-central involved DME (N = 1), no central-involved DME and definite/possible non-central involved DME (N = 1) and the possible central-involved and definite/possible non-central involved DME (N = 3) groups respectively in the analysis.

^**Eleven eyes did not have, and 6 eyes had, history of DME treatment.