TABLE 2.
Tissue-Specific Cre-Expressing Mouse Lines
| Specificity | Promoter | Transgene | Reference |
|---|---|---|---|
| Ubiquitous | Human cytomegalovirus (CMV) | CMV-Cre CreERT2 CMV |
Schwenk et al. (1995), Feil et al. (1996) |
| Ubiquitous | Rosa26 | Rosa26-Cre | Soriano (1999) |
| Adipocytes | aP2 | aP2-Cre | Barlow et al. (1997) |
| B-lymphocytes | CD-19 gene albumin | Cd19-Cre Cd-19-CreERT2 |
Rickert et al. (1997), Boross et al. (2009) |
| Brain (neurons) | Calbindin 2 | Calb2-CreERT2 | Taniguchi et al. (2011) |
| Cardiac muscle | α-Myosin heavy chain (α-MHC) | α-MHC-Cre | Gupta et al. (1998) |
| Central nervous system (hippocampus) |
Mouse pro-opiomelanocortin-alpha (POMC) | POMC-Cre | McHugh et al. (2007) |
| Colonic epithelium | Human caudal type homeo-box 2 (CDX2) | CDX2-Cre | Hinoi et al. (2007) |
| Epiblast cells | Mouse SRY-box containing gene 2 (Sox2) | Sox2-Cre | Hayashi and McMahon (2002) |
| Kidney epithelium | Gamma-glutamyltransferase 1(Ggt1) | Ggt1-Cre | Iwano et al. (2002) |
| Liver (hepatocytes) | Albumin promoter/enhancer (Alb) | Alb-Cre Alb-CreERT2 |
Postic and Magnuson (1999), Schuler et al. (2004) |
| Lung (endoderm) | Human surfactant pulmonary-associated protein C (SFTPC) |
SFTPC-Cre | Okubo and Hogan (2004) |
| Mammary gland | Whey acidic protein (Wap) | Wap-Cre | Wagner et al. (1997) |
| Midbrain/hindbrain | Mouse engrailed 2 promoter/enhancer (En2) | En2-Cre | Sgaier et al. (2005) |
| Pancreatic epithelium | Pancreatic and duodenal homeobox1 (pdx1) | Pdx1-Cre | Gannon et al. (2000a) |
| Pancreatic β-cells | Rat insulin II | Ins2-Cre | Gannon et al. (2000b) |
| Skeletal muscle | Mouse muscle creatine kinase (MCK) | MCK-Cre | Levin et al. (2007) |
| Skin (keratinocytes) | Human keratin 14 | K14-Cre K14-CreERT2 |
Dassule et al. (2000), Vasioukhin et al. (1999) |
| Small and large intestine (crypts) |
Mouse villin 1 | Vil-Cre Vil-CreERT2 |
Madison et al. (2002), Vasioukhin et al. (1999) |
| Small and large intestine (epithelium) |
Fatty acid binding protein (Fabp) | Fabpl-Cre | Saam and Gordon (1999) |
| Small and large intestine (epithelium) |
Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) |
Lgr5-EGFP-IRES- CreERT2 |
Barker et al. (2007) |