Table 2.
The Association of Ectopic Fat Depots with Incident CVD (n=90), Cancer (n=141), and All-cause Mortality (n=71). A p-value of <0.017 was considered statistically significant
| Age-sex adjusted model | p-value | MV* Model | p-value | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| CVD | ||||
| Visceral Adipose Tissue | 1.48 (1.21–1.81) | <0.001 | 1.44 (1.08–1.92)† | 0.014 |
| Periaortic Fat | 1.41 (1.16–1.71) | <0.001 | 1.31 (1.03–1.67) | 0.03 |
| Pericardial Fat | 1.24 (1.05–1.46) | 0.01 | 1.11 (0.91–1.35) | 0.3 |
| Subcutaneous Adipose Tissue | 1.23 (0.99–1.53) | 0.06 | 0.99 (0.66–1.49) | 1.0 |
| Cancer | ||||
| Visceral Adipose Tissue | 1.22 (1.03–1.46) | 0.03 | 1.43 (1.12–1.84) | 0.005 |
| Periaortic Fat | 1.21 (1.02–1.44) | 0.03 | 1.22 (0.99–1.50) | 0.06 |
| Pericardial Fat | 1.20 (1.05–1.39) | 0.02 | 1.17 (0.98–1.38) | 0.08 |
| Subcutaneous Adipose Tissue | 0.98 (0.82–1.18) | 0.9 | 0.90 (0.65–1.26) | 0.5 |
| All-Cause Mortality | ||||
| Visceral Adipose Tissue | 1.26 (1.01–1.57) | 0.04 | 1.05 (0.77–1.43) | 0.7 |
| Periaortic Fat | 1.28 (1.05–1.55) | 0.01 | 1.08 (0.85–1.38) | 0.5 |
| Pericardial Fat | 1.31 (1.10–1.55) | 0.002 | 1.17 (0.95–1.44) | 0.1 |
| Subcutaneous Adipose Tissue | 1.07 (0.81–1.40) | 0.7 | 0.72 (0.45–1.15) | 0.2 |
Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; VAT, visceral adipose tissue
*
MV (multivariable) models - adjusted for age, sex, systolic blood pressure, diabetes, total cholesterol, HDL cholesterol, current smoking, hypertension treatment, and BMI
†
For the CVD outcome, the integrated discrimination index was 0.082 (95% confidence interval −0.003, 0.176) after the addition of VAT to the multivariable model. The chi square statistic (p-value) for model calibration was 12.9 (p=0.2), suggesting good calibration.