Table 3.

Association of multiple fat depots with incident CVD (40 events in women, 50 events in men) and incident cancer (68 events in women, 73 events in men) stratified by sex.

Adiposity Measure	Women (N=1519)		Men (N=1567)		p-interaction†
	Age-adjusted	MV Model	Age-adjusted	MV Model
Incident CVD
		HR (95% CI)		HR (95% CI)
Visceral Adipose Tissue	1.20 (0.90–1.59)	1.04 (0.65–1.65)	1.64 (1.27–2.11)	1.66 (1.16–2.39)	0.1
Periaortic Fat	1.19 (0.91–1.56)	1.08 (0.75–1.55)	1.47 (1.16–1.85)	1.37 (1.02–1.84)	0.5
Pericardial Fat	1.13 (0.85–1.49)	0.97 (0.69–1.36)	1.28 (1.05–1.55)	1.16 (0.91–1.47)	0.4
Subcutaneous Adipose Tissue	1.24 (0.90–1.71)	1.33 (0.72–2.45)	1.22 (0.93–1.61)	0.79 (0.47–1.33)	1.0
Incident Cancer
Visceral Adipose Tissue	1.19 (0.94–1.49)	1.27 (0.88–1.82)	1.20 (0.96–1.49)	1.43 (1.06–1.94)	0.4
Periaortic Fat	1.28 (1.02–1.62)	1.31 (0.97–1.77)	1.11 (0.90–1.38)	1.13 (0.86–1.49)	1.0
Pericardial Fat	1.06 (0.83–1.35)	0.96 (0.72–1.29)	1.25 (1.05–1.48)	1.24 (1.02–1.51)	0.06
Subcutaneous Adipose Tissue	1.00 (0.78–1.28)	0.80 (0.49–1.30)	0.98 (0.76–1.27)	0.99 (0.64–1.54)	0.9
All–cause Death
Visceral Adipose Tissue	1.12 (0.77–1.62)	1.18 (0.66–2.14)	1.27 (0.99–1.62)	0.92 (0.65–1.28)	0.3
Periaortic Fat	1.06 (0.72–1.55)	1.05 (0.64–1.71)	1.28 (1.04–1.58)	0.95 (0.72–1.24)	0.2
Pericardial Fat	1.11 (0.77–1.60)	1.09 (0.73–1.64)	1.36 (1.12–1.65)	1.16 (0.91–1.46)	0.2
Subcutaneous Adipose Tissue	0.84 (0.54–1.32)	0.73 (0.32–1.63)	1.26 (0.91–1.74)	0.74 (0.41–1.33)	0.2

Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; VAT, visceral adipose tissue

^*MV (multivariable) models - adjusted for age, systolic blood pressure, diabetes, total cholesterol, HDL cholesterol, current smoking, hypertension treatment, and BMI

^†p-interaction is age-adjusted