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. 2014 Aug 25;8:246. doi: 10.3389/fncel.2014.00246

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Copyright © 2014 Nieus, Mapelli and D'Angelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of E/I and pE/pI in controlling granule cell firing parameters in response to mossy fiber bursts. (A) (Top) The relative changes of number of spikes (ns), time window (tw), time to first spike (ttfs) and first spike standard deviation (fssd) in control (con, black) and after switch off of α1 (α1-OFF, gray) or α6 (α6-OFF, light gray) receptors is shown for the low-E/I and high-E/I quadrants identified in Figure 4B. It should be noted that the E/I balance primarily affects ns and tw.(Bottom) The relative change of number of spikes (ns), time window (tw), time to first spike (ttfs) and first spike standard deviation (fssd) is compared with phasic inhibition off (phasic OFF) and tonic inhibition off (tonic OFF). Blocking tonic inhibition does not influence notably the effect of phasic inhibition on the time-related spiking parameters, time to first spike and first spike standard deviation. (B) The relative changes of number of spikes (ns), time window (tw), time to first spike (ttfs) and first spike standard deviation (fssd) are reported as a function of the inhibitory (and excitatory release probability (Pi, Pe), showing that Pi affects modestly the parameters, while raising Pe remarkably increases number of spikes and decreases time to first spike and first spike standard deviation.