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. 2014 Aug 25;8:246. doi: 10.3389/fncel.2014.00246

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Copyright © 2014 Nieus, Mapelli and D'Angelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resonance of the parameter distributions at different E/I levels. (A) Exemplar fitting with a Lorentzian function (Equation 4) applied to the phase-lag plot (cf. Figure 7B) indicating the geometrical meaning of the parameters Q, A, ω, θ_max. (B) The average values of Lorentzian parameters during α1 or α6 switch-off are reported for number of spikes (ns), time window (tw), time to first spike (ttfs), first spike standard deviation (fssd), VDCC current and NMDA current. Note that Q(α6) and ω(α6) is always larger than Q(α1) and ω(α1), while θ_max(α6) is negative and θ_max(α1) is positive. These data are averaged over the whole parameter response space. (C) The top panel shows the Q factors of the α6_OFF difference phase-lag curves (α6_OFF-CTRL). Note that Q of time window (tw), time to first spike (ttfs) and first spike standard deviation (fssd) decrease with increasing E/I, while the other parameters are much less affected. The bottom panel shows the difference Q factors obtained as Q (tonic OFF)–Q (tonic ON). Note that the trends of these Q plots is qualitatively similar to that reported above. (D) Precession of θ_max(α6) for the NMDA Q factor. The phase of the peak (color coded) increases with increasing E/I.