Table 2.
Association between alleles of SNPs at 6p21.3 and NPC in phase I and phase II combined.
| Gene-SNP | Risk allele | Phase I and phase II | Phase I and phase II | Phase II | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI)∗ | P* | OR (95% CI)∗∗ | P** | OR (95% CI)∗∗∗ | P*** | ||
| GABBR1-rs2267633 | A | 1.61 (1.41–1.84) | 1.02E − 12 | 1.48 (1.17–1.87) | 0.001 | 1.41 (1.02–1.95) | 0.03 |
| GABBR1-rs29230 | T | 1.64 (1.45–1.89) | 1.36E − 13 | 1.61 (1.28–2.04) | 6.14E − 05 | 1.61 (1.16–2.22) | 0.004 |
| GABBR1-rs29232 | A | 1.35 (1.21–1.49) | 1.85E − 08 | 1.41 (1.16–1.71) | 0.0006 | 1.33 (1.01–1.76) | 0.05 |
| HLA-F-rs3129055 | G | 1.14 (1.02–1.28) | 0.02 | 1.33 (1.09–1.64) | 0.008 | 1.47 (1.10–1.20) | 0.01 |
| HLA-A-rs2517713 | T | 1.61 (1.43–1.82) | 2.44E − 16 | 1.69 (1.35–2.08) | 2.58E − 06 | 1.64 (1.20–2.22) | 0.003 |
| HCG9-rs9260734 | G | 1.67 (1.47–1.87) | 5.96E − 17 | 1.75 (1.41–2.17) | 6.48E − 07 | 1.75 (1.28–2.44) | 0.0005 |
| HCG9-rs3869062 | A | 1.60 (1.42–1.81) | 3.4E − 14 | 1.63 (1.30–2.04) | 1.97E − 05 | 1.60 (1.16–2.19) | 0.004 |
| HCG9-rs5009448 | C | 1.62 (1.45–1.82) | 1.89E − 16 | 1.66 (1.33–2.06) | 3.46E − 06 | 1.64 (1.20–2.26) | 0.002 |
| HCG9-rs16896923 | T | 1.54 (1.35–1.75) | 4.56E − 11 | 1.69 (1.33–2.13) | 2.19E − 05 | 1.64 (1.18–2.27) | 0.005 |
OR: odds ratio. CI: confidence interval.
∗Adjusted for sex and age.
∗∗Additionally adjusted for EBV/IgA/VCA and EBV/IgA/EA titers.
∗∗∗Additionally adjusted for EBV/IgA/VCA and EBV/IgA/EA antibody titers and other environmental factors including family history with NPC, consumption of salt-preserved fish, exposure to domestic wood cooking fires, and exposure to occupational solvents.