Table 1.
Blood chemistry measurements in OMV-immunized and control-immunized macaques. Blood was collected from animals at indicated time points and analyzed using a CBC chemistry panel.IN71, II81 – OMV-immunized; HM73, DJ17 – controls.
| IN71 | Pre-vaccination | Prime 25μg | Boost 50 μg +28 | 2nd Boost 100μg +56 | End Point +85 | II81 | Pre-vaccination | Prime 25μg | Boost 50 μg +28 | 2nd Boost 100μg +56 | End Point +85 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| +1 | +2 | +3 | +1 +2 +3 | ||||||||||||
| ALT (20-126 U/L) | 17 | 36 | 39 | 43 | 17 | 15 | 27 | ALT (20-126 U/L) | 32 | 37 | 47 | 50 | 39 | 39 | 44 |
| AST (25-120 U/L) | 25 | 48 | 50 | 52 | 23 | 22 | 32 | AST (25-120 U/L) | 67 | 33 | 36 | 40 | 36 | 25 | 46 |
| Albumin (3-5.9 g/dL) | 4.3 | 4.0 | 3.9 | 4.2 | 4.2 | 4.3 | 3.7 | Albumin (3-5.9 g/dL) | 4.0 | 4.0 | 3.7 | 4.0 | 4.3 | 4.3 | 3.3 |
| BUN (13-27 mg/dL) | 21 | 18 | 17 | 20 | 19 | 19 | 14 | BUN (13-27 mg/dL) | 14 | 15 | 19 | 19 | 20 | 23 | 21 |
| WBC (6.6-15.5 × 103/UL) | 11.74 | 14.26 | 7.65 | 7.14 | 7.71 | 10.28 | 9.00 | WBC (6.6-15.5 × 103/UL) | 12.49 | 13.96 | 16.01 | 11.89 | 6.7 | 10.84 | 11.10 |
| Neutrophil # (1.4-7.3.0× 103/UL) | 6.71 | 10.14 | 3.51 | 3.25 | 2.65 | 5.03 | 3.10 | Neutrophil # (1.4-7.3.0× 103/UL) | 8.13 | 10.22 | 11.96 | 7.76 | 2.11 | 6.32 | 4.80 |
| Lymphocyte # (2.3-13× 103/UL) | 4.06 | 3.15 | 2.96 | 3.17 | 4.07 | 4.28 | 4.60 | Lymphocyte # (2.3-13× 103/UL) | 3.63 | 3.12 | 3.39 | 3.62 | 4.07 | 3.88 | 4.40 |
| Monocyte # (0.1-1.5× 103/UL) | 0.44 | 0.58 | 0.50 | 0.37 | 0.51 | 0.59 | 1.30 | Monocyte # (0.1-1.5× 103/UL) | 0.37 | 0.43 | 0.32 | 0.32 | 0.28 | 0.35 | 1.90 |
| HM73 | Pre-vaccination | Prime 25μg | Boost 50 μg +28 | 2nd Boost 100μg +56 | End Point +85 | DJ17 | Pre-vaccination | Prime 25μg | Boost 50 μg +28 | 2nd Boost 100μg +56 | End Point +85 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| +1 | +2 | +3 | +1 +2 +3 | ||||||||||||
| ALT (20-126 U/L) | 23 | 22 | 29 | 34 | 26 | 24 | 30 | ALT (20-126 U/L) | 29 | 38 | 29 | 69 | 32 | 31 | 42 |
| AST (25-120 U/L) | 26 | 20 | 31 | 38 | 30 | 27 | 26 | AST (25-120 U/L) | 25 | 43 | 31 | 54 | 22 | 28 | 29 |
| Albumin (3-5.9 g/dL) | 4.2 | 4.2 | 4.1 | 4.3 | 4.4 | 4.5 | 3.5 | Albumin (3-5.9 g/dL) | 4.1 | 4.1 | 4.1 | 4.1 | 4.2 | 4.4 | 3.3 |
| BUN (13-27 mg/dL) | 15 | 20 | 20 | 18 | 18 | 21 | 15 | BUN (13-27 mg/dL) | 19 | 19 | 20 | 15 | 14 | 17 | 15 |
| WBC (6.6-15.5 × 103/UL) | 13.34 | 9.31 | 10.50 | 11.11 | 10.18 | 14.92 | 8.60 | WBC (6.6-15.5 × 103/UL) | 9.13 | 9.13 | 10.50 | 7.50 | 8.52 | 9.48 | 8.40 |
| Neutrophil # (1.4-7.3.0× 103/UL) | 9.21 | 4.66 | 5.63 | 6.16 | 4.50 | 8.11 | 2.40 | Neutrophil # (1.4-7.3.0× 103/UL) | 5.33 | 5.33 | 4.86 | 5.01 | 5.70 | 6.18 | 2.09 |
| Lymphocyte # (2.3-13× 103/UL) | 3.10 | 3.53 | 3.54 | 4.08 | 4.95 | 5.30 | 5.00 | Lymphocyte # (2.3-13× 103/UL) | 3.00 | 3.00 | 2.40 | 1.77 | 2.02 | 2.77 | 2.30 |
| Monocyte # (0.1-1.5× 103/UL) | 0.66 | 0.61 | 0.55 | 0.38 | 0.46 | 0.66 | 1.20 | Monocyte # (0.1-1.5× 103/UL) | 0.29 | 0.29 | 0.30 | 0.21 | 0.37 | 0.25 | 3.20 |