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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jun 12;24(16):4031–4034. doi: 10.1016/j.bmcl.2014.06.002

Table 3.

Inhibitory activity of linker modified analogs.

graphic file with name nihms611367u3.jpg
# L Ar2 hPDE4B IC50 (nM) hPDE4D IC50 (nM) Ratio D/B IC50
8 NH graphic file with name nihms611367t13.jpg 237 1181 5.0
14 NHCH2 graphic file with name nihms611367t14.jpg 2282 859 0.38
15 NHCH2 graphic file with name nihms611367t15.jpg 845 726 0.86
16 O graphic file with name nihms611367t16.jpg 1862 2268 1.2