TABLE 2.

2010 American Association of Clinical Endocrinologists Protocol for Production of Clinical Practice Guidelines–Step II: Evidence Analysis and Subjective Factors

Study design	Data analysis	Interpretation of results
Premise correctness	Intent-to-treat	Generalizability
Allocation concealment (randomization)	Appropriate statistics	Logical
Selection bias		Incompleteness
Appropriate blinding		Validity
Using surrogate end points (especially in “first-in-its-class” intervention)
Sample size (beta error)
Null hypothesis versus
Bayesian statistics