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. 2014 Aug 15;25(16):2393–2407. doi: 10.1091/mbc.E14-02-0705

FIGURE 11:

FIGURE 11:

Model for LIMK-mediated regulation of cleft stabilization and cleft progression in mouse E13 salivary glands undergoing branching morphogenesis. Schematic diagram of a proposed model for LIMK-mediated cytoskeletal changes regulating cleft formation: LIMK via cofilin and TPPP/p25 exerts multistep control of cleft formation by affecting focal adhesion assembly and activation and integrin activation to regulate cleft stabilization, and FN assembly and cell proliferation to regulate cleft progression.