FIGURE 5:

Nup50 dynamics are uniquely affected by transcription targeting intercalators. (A) Schematic of transcription inhibiting drugs used and their modes of action. i) Intercalators; ii) inhibitors of RNA Pol II regulatory phosphorylation; iii) competitive inhibitors of transcription initiation. (B) Summary of FRAP analysis of nucleoplasmic Nup50 in the presence of the indicated transcriptional inhibitors; see Material and Methods and Supplemental Table S1 for durations and concentrations of drugs used. N > 8 cells/condition. Bars, SEM. *p < 0.05 by t test.