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. 2014 Jul 14;1:391–400. doi: 10.1016/j.toxrep.2014.07.003

Fig. 1.

Fig. 1

BPDE-DNA adducts are formed and detected in RPTEC/TERT1 cells after exposure to B[a]P but reduced under co-exposure to 1 μM Cd and 1 μM B[a]P. After 18 and 24 h of treatment with B[a]P a significant increase in the number of adducts was detected at 1 μM B[a]P. Treatment of cells for 24 h with 1 μM Cd before a 24 h exposure to concentrations of B[a]P showed a significant decrease in adducts detected at 1 μM B[a]P in comparison to B[a]P alone. Bars represent average adducts/108 nucleotides (n = 3) ± SEM. *Significant difference from 1 μM B[a]P at 18 h, p < 0.01, +Significant difference from 1 μM B[a]P at 24 h, p < 0.01.