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. 1979 Apr;24(1):102–105. doi: 10.1128/iai.24.1.102-105.1979

Clearance of bacteria from cerebrospinal fluid to blood in experimental meningitis.

W M Scheld, T S Park, R G Dacey, H R Winn, J A Jane, M A Sande
PMCID: PMC414268  PMID: 37164

Abstract

The occurrence and importance of secondary bacteremia in the pathogenesis of and response to therapy in meningitis is uncertain. Streptococcus pneumoniae type III was injected into the cerebrospinal fluid of the cisterna magna in anesthetized, curarized dogs, and sequential simultaneous samples were obtained from the superior sagittal sinus, cisterna magna, and peripheral blood. The results show that: (i) bacteria are rapidly transported from the cerebrospinal fluid to blood but only after active multiplication within the cerebrospinal fluid, and (ii) entrance into the blood from the cerebrospinal fluid occurs before the height of the febrile response or cerebrospinal fluid pleocytosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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