Table 3.
Association of Cardiac Biomarkers with Echocardiographic Z-scores for 94 Children in SMARTT having an Echocardiogram within 3 months of Biomarker Assay
| Comparison of Adjusted* Mean Echocardiographic Z-score between Children with Elevated versus Normal Cardiac Biomarker Levels | Correlation of Z-scores with Continuous Biomarker Level | ||||
|---|---|---|---|---|---|
| Echocardiographic Z-score | Elevated Biomarker Mean (SE) | Normal Biomarker Mean (SE) | P Value | Spearman Correlation Coefficient | P Value |
| hsCRP | |||||
| Contractility | −0.37 (0.24) | 0.21 (0.12) | 0.04 | −0.09 | 0.41 |
| ED Septal Thickness | −0.41 (0.19) | −0.18 (0.10) | 0.30 | −0.22 | 0.03 |
| NT-proBNP | |||||
| LV ED Dimension | 0.29 (0.22) | −0.11 (0.10) | 0.12 | 0.20 | 0.05 |
| ES Septal Thickness | −0.89 (0.20) | −0.39 (0.09) | 0.03 | −0.05 | 0.65 |
| cTnT | |||||
| LV ED Posterior Wall Thickness | 0.33 (0.24) | −0.21 (0.11) | 0.04 | 0.20 | 0.06 |
| LV Thickness-to-Dimension Ratio | −0.10 (0.22) | −0.61 (0.10) | 0.04 | 0.21 | 0.04 |
NT-proBNP=N-terminal pro-brain natriuretic peptide; hsCRP=high-sensitivity C-reactive protein; cTnT=cardiac troponin T, LV=Left ventricular; ED=End-diastolic.