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. 2014 Jul 25;7(9):1057–1068. doi: 10.1242/dmm.016535

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Bilirubin reduces dendrite complexity and spine density of PCs. Comparison of PCs from WT and P0–P8 PT-treated FVB/NJ-Ugt1^−/− mice at P15 (four mice/genotype). (A) Total dendritic length (μm). t-test analysis. *P≤0.05. (B) Number of branches. t-test analysis. *P≤0.05. (C) Average dendritic length (μm). t-test, not significant. (D) Sholl-analysis-derived distribution of PCs and mean number of intersections of dendrite branches. t-test analysis. *P≤0.05; **P≤0.01. (E,F) Spine density (%) and representative pictures of PC spines in WT and P0–P8 PT-treated mutant mice at P15. Mann-Whitney test analysis. *P≤0.01. Scale bar: 5 μm.