Skip to main content
. 2014 Sep;7(9):1083–1091. doi: 10.1242/dmm.014878

Fig. 7.

Fig. 7.

Liver nodules in aging LS-G6pc−/− mice. (A) Liver resection of a 19-month-old LS-G6pc−/− mouse with a 10 mm nodule (arrow). Smaller nodules are also present (arrowhead). (B) H&E-stained section from the liver of a 12-month-old LS-G6pc−/− mouse showing a nodule histologically characterized as HCA (boundary shown as dotted line). (C) A higher magnification (H&E stained) of the same nodule showing normal hepatocytes, a solitary artery and no portal tracts, typical of HCA. (D) H&E-stained section of the liver of a 19-month-old LS-G6pc−/− mouse showing a HCC within a HCA (boundary shown as dotted line). (E) Higher magnification of the HCC, showing thickened hepatocyte plates with trabecular and pseudoglandular architecture and evident cytological atypia with scattered mitoses. (F) HCC stained with reticulin stain, showing loss of reticulin framework typical of malignancy. Reticulin stain was preserved in the surrounding HCA. (B) 4× magnification; (C,D) 20× magnification; (E) 40× magnification; (F) 10× magnification.