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. 2014 Jul 4;7(9):1093–1100. doi: 10.1242/dmm.015537

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Reduction of Keap1 in the liver by siRNA administration in vivo attenuates ConA-induced liver damage. Analysis of Keap1 expression and histopathological features in liver samples from luciferase siRNA (siLuc) or Keap1 siRNA (siKeap1) mice after 4 and 8 hours of ConA treatment (n=4–6 animals per condition). (A) (left panel) Keap1 mRNA levels determined by real-time PCR. (Right panel) Representative blots with the indicated antibodies and quantification of the densitometric analysis from all blots. Data are presented as mean±s.e.m. relative to siLuc mice. (B) Cbr3 and Nqo1 mRNA levels determined by real-time PCR. Data are presented as mean±s.e.m. relative to siLuc mice. (C) Representative images from hematoxylin and eosin staining. ***P<0.005, siKeap1 versus siLuc.