Table 1.
Baseline Characteristics of the Study Participants.*
| Characteristic | Testosterone Dose | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 g/day | 1.25 g/day | 2.5 g/day | 5 g/day | 10 g/day | ||||||
| Cohort 1 (N = 41) | Cohort 2 (N = 38) | Cohort 1 (N = 41) | Cohort 2 (N = 38) | Cohort 1 (N = 34) | Cohort 2 (N = 43) | Cohort 1 (N = 38) | Cohort 2 (N = 42) | Cohort 2 (N = 44) | Cohort 2 (N = 41) | |
| Age (yr) | 32±9 | 34±7 | 34±7 | 33±7 | 32±8 | 33±7 | 34±8 | 33±6 | 33±8 | 34±6 |
| Height (cm) | 179±6† | 175±6 | 177±6 | 177±6 | 176±6 | 177±8 | 173±7‡ | 176±7 | 177±8 | 177±6 |
| Weight (kg) | 84±14 | 84±15 | 84±14 | 87±17 | 78±15 | 83±14 | 78±14‡ | 87±15 | 85±18 | 83±12 |
| Body-mass index§ | 26±4 | 27±5 | 27±4 | 28±5 | 25±4 | 26±4 | 26±4 | 28±5 | 27±5 | 26±4 |
| Testosterone (ng/dl) | 510±160 | 511±181 | 506±154 | 548±189 | 574±125 | 512±159 | 506±138 | 514±176 | 529±140 | 517±151 |
| Estradiol (pg/ml) | 27±8‡ | 32±10 | 27±8‡ | 32±10 | 32±10 | 30±13 | 27±8 | 30±10 | 29±9 | 27±9 |
| Percentage of body fat | 22.3±6.3 | 22.9±6.3 | 23.3±6.5 | 20.8±6.7 | 19.9±6.0 | 20.4±6.9 | 22.4±6.2 | 22.9±5.8 | 22.5±6.4 | 20.1±5.1 |
| Total-body lean mass (g) | 59,098±7073 | 56,896±8551 | 59,074±7834 | 59,263±8291 | 55,435±7130 | 57,418±7448 | 55,662±7523 | 59,103±9025 | 58,412±10,406 | 58,042±7658 |
| Subcutaneous-fat area (mm2) | 22,425±11,807 | 23,507±12,758 | 23,178±11,176 | 23,021±15,351 | 18,262±10,823 | 18,724±10,427 | 21,050±9868 | 25,339 ±11875 | 21,772±12,814 | 19,563±8740 |
| Intraabdominal-fat area (mm2)¶ | 10,987±6905 | 9504±4988 | 10,251±6916 | 8551±5431 | 7521±5153 | 8153±5352 | 10,023±6619 | 9996±6154 | 9582±5406 | 7964±5219 |
| Thigh-muscle area (mm2) | 17,082±2772 | 16,769±2668 | 16,810±2899 | 17,964±2926 | 16,478±2722 | 17,265±2711 | 16,579±2427 | 17,558±2654 | 16,905±3395 | 17,226±2361 |
| Leg press (lb) | 613±152 | 645±171 | 592±127† | 701±195 | 612±167 | 627±155 | 582±122† | 641±137 | 633±173 | 662±170 |
Plus–minus values are means ± SD. There were no significant differences between cohort 1 and cohort 2 for groups assigned to the same testosterone dose unless otherwise indicated. To convert the values for testosterone to nanomoles per liter, multiply by 0.03467. To convert the values for estradiol to picomoles per liter, multiply by 3.671. To convert the values for leg press to kilograms, multiply by 0.45.
P<0.01 with the use of a nonpaired t-test for the comparison with cohort 2.
P<0.05 with the use of a nonpaired t-test for the comparison with cohort 2.
The body-mass index is the weight in kilograms divided by the square of the height in meters.
P<0.05 with the use of one-way analysis of variance for comparisons across dose groups in cohort 1.