FIG. 6.

GPD1L expression in breast, CCRC, and lung adenocarcinoma (data from The Cancer Genome Atlas). Data publicly available from the Cancer Genome Atlas Project (TCGA; http://tcga-data.nci.nih.gov/) were analyzed for mRNA, miRNA expression. Log-rank test was employed to determine the relationship between expression and overall survival and the Kaplan–Meyer method was used to generate survival curves. The entire population in training/validation cohorts was randomly split (2/3, 1/3) and for each miRNA, we checked for a relation with the survival as follows. In both cohorts, patients were divided into percentiles according to miRNA expression. Using the training set, we considered any cut-off between 25th and 75th to significantly split the samples into two groups and checked for statistical significance in the validation set. We then chose the cut-off value to optimally split the samples in both cohorts. Further details in Supplementary Data.