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The antagonist responses of (◯) SB657510, (△) GSK1562590, and (□) urantide as reference compounds. Dose–response curves were generated in the (A) dynamic mass redistribution assay and (B) calcium mobilization assay. Each assay was conducted as described in the Materials and Methods section. The percent inhibition was calculated as ([raw data of compound−Meanc−]/[Meanc+−Meanc−]) × 100. Data were expressed as the mean±SD of percent inhibition (n=3).
