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miR-210 in the iron homeostasis pathway. miR-210 suppresses the iron-sulfur cluster assembly proteins, ISCU1 and ISCU2, inhibiting electron transport chain activity. Inhibition of ISCU1/2 indirectly induces the iron transport protein transferrin receptor (TfR) and increases the uptake of iron. MiR-210 directly suppresses TfR, inhibiting this side effect of ISCU1/2 regulation.
