. Author manuscript; available in PMC: 2014 Aug 25.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2010 Nov 15;91(1):44–49. doi: 10.1002/bdra.20737

Table 4.

Folate Pathway and CRISPLD2 Gene Interactions

Ethnicity	Gene/SNP	CRISPLD2 SNP	p-value^*
nonHispanic white	BHMT/rs645112	rs1874014	0.009
	BHMT/rs3733890	rs16974880	0.01
	BHMT2/rs2253262	rs1874014	0.0005
	BHMT2/rs682985	rs1874014	0.001
	BHMT2/rs1422086	rs1874014	0.003
	FOLR1/rs3016432	rs2646112	0.007
	FOLR2/rs2276048	rs2646112	0.005
	MTHFD1/rs2236222	rs12051468	0.008
	MTHFD2/rs7587117	rs2641670	0.003
	MTHFR/rs1476413	rs8051428	0.007
	MTHFS/rs2586179	rs1874015	0.003
	MTHFS/rs2586179	rs767050	0.009
	MTR/rs12354209	rs1546124	0.0009
	MTR/rs12354209	rs1874015	0.007
	MTR/rs1266164	rs1546124	0.004
	NOS3/rs1800779	rs16974880	0.005
	NOS3/rs2373929	rs16974880	0.005
	TYMS/rs11540152	rs2646129	0.008
	TYMS/rs2853532	rs12051468	0.010
Hispanic	CBS/rs2851391	rs2646112	0.009
	FOLR1/rs2071010	rs774206	0.006
	FOLR1/rs2071010	rs721005	0.009
	MTHFD1/rs2236222	rs12051468	0.003
	MTHFD1/rs11849530	rs2641674	0.006
	MTHFR/rs1801131	rs2646112	0.003
	MTHFR/rs1476413	rs2646112	0.003
	MTHFR/rs535107	rs8061351	0.007
	SLC19A1/rs3788205	rs4783099	0.01
	TYMS/rs495139	rs8061351	0.002
	TYMS/rs1001761	rs8061351	0.003

p-value≤0.01