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. 1979 Apr;24(1):286–288. doi: 10.1128/iai.24.1.286-288.1979

Inhibition of adenosine 3',5'-monophosphate-dependent protein kinase by staphylococcal alpha-toxin.

I Kato, M Watanabe, N H Kumazawa
PMCID: PMC414295  PMID: 222682

Abstract

Staphylococcal alpha-toxin inhibited the activity of cyclic adenosine 3',5'-monophosphate-dependent protein kinase by competitive inhibition, probably by its interaction with a cyclic adenosine 3',5'-monophosphate-binding site in the protein kinase molecule.

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Selected References

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  1. Corbin J. D., Sugden P. H., West L., Flockhart D. A., Lincoln T. M., McCarthy D. Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem. 1978 Jun 10;253(11):3997–4003. [PubMed] [Google Scholar]
  2. Demaille J. G., Peters K. A., Fischer E. H. Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3',5'-monophosphate dependent protein kinases. Biochemistry. 1977 Jul 12;16(14):3080–3086. doi: 10.1021/bi00633a006. [DOI] [PubMed] [Google Scholar]
  3. Gilman A. G. A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A. 1970 Sep;67(1):305–312. doi: 10.1073/pnas.67.1.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kato I., Naiki M. Ganglioside and rabbit erythrocyte membrane receptor for staphylococcal alpha-toxin. Infect Immun. 1976 Jan;13(1):289–291. doi: 10.1128/iai.13.1.289-291.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kato I., Sakoda K., Saito M., Suzuki Y., Watanabe M. Inhibitory effect of flavin mononucleotide on the hemolysis of rabbit erythrocytes by staphylococcal alpha-toxin. Infect Immun. 1975 Sep;12(3):696–697. doi: 10.1128/iai.12.3.696-697.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Langan T. A. Protein kinases and protein kinase substrates. Adv Cyclic Nucleotide Res. 1973;3:99–153. [PubMed] [Google Scholar]
  7. Miyamoto E., Kuo J. F., Greengard P. Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. J Biol Chem. 1969 Dec 10;244(23):6395–6402. [PubMed] [Google Scholar]
  8. Righetti P., Drysdale J. W. Isoelectric focusing in polyacrylamide gels. Biochim Biophys Acta. 1971 Apr 27;236(1):17–28. doi: 10.1016/0005-2795(71)90144-9. [DOI] [PubMed] [Google Scholar]
  9. Watanabe M., Kato I. Purification and some properties of a lethal toxic fragment of staphylococcal alpha-toxin by tryptic digestion. Biochim Biophys Acta. 1978 Aug 21;535(2):388–400. doi: 10.1016/0005-2795(78)90104-6. [DOI] [PubMed] [Google Scholar]
  10. Watanabe M., Kato I. Purification and some properties of staphylococcal alpha-toxin. Jpn J Exp Med. 1974 Apr;44(2):165–178. [PubMed] [Google Scholar]

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