Figure 2.

Higher eukaryotic mitosis. In higher eukaryotic prophase, the nuclear membrane begins to degrade on the onset of chromosome condensation. In fungi, such as yeast, the nuclear membrane remains during mitosis. Centrosomes (called “spindle pole bodies” in yeast) are duplicated and begin to form the mitotic spindle. In prometaphase, the full spindle forms and condensed chromosomes are attached to kinetochore microtubules. In metaphase, chromosomes are aligned at the middle. In anaphase A, sister chromatids are pulled toward opposite poles. In anaphase B, spindle extension occurs. Finally, in telophase, the nuclear membrane reforms.