Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Representative 2D free-energy surfaces as a function of the hydrophobic core size and the L12-G2 loop rmsd. All rmsd values were calculated relative to the NMR structure, which had a hydrophobic core size of ∼3.6 Å. All ΔS were calculated with respect to KIX-free at 300 K (Methods and Table 1).
