Fig. 6.

Certain patients show a rebound trend in a subset of miRNAs after stopping NAC treatment. Profiles of ALT, miRNA changes, and sample time point are shown for seven patients that show rebound in miRNA profiles after stopping treatment with NAC. (A) NAC treatment period is shaded with gray. Patients are labeled with patient ID and color-coded according to their peak ALT as in Fig. 1. (B) Heatmaps for six miRNAs that showed a ΔΔCT ≥ 3 after APAP overdose, recovered by ΔΔCT ≥ 3 after NAC treatment, and then rose again by ΔΔCT ≥ 1.5 after NAC treatment, in at least five of the seven patients.