Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthetic scheme of the polymer–drug conjugate. (A) The carboxylic acid moiety of diclofenac 1 is activated with 1,1′-carbonyldiimidazole and subsequently esterified with TriEG to form the TriEG-Diclof prodrug 2. (B) After purification, 2 is then conjugated to poly(l-glutamic acid) via Steglich esterification with N,N′-dicyclohexylcarbodiimide and 4-dimethylaminopyridine to yield the PGA-TriEG-Diclof conjugate 3.
