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Signaling networks of mRNAs involved in lncRNA-mRNA relationships. MetaCore analysis of functional networks involving regulated cardiac mRNAs linked to regulated cardiac lncRNAs. Green arrows, up-regulation; red arrows, down-regulation; gray lines, context-dependent interaction. Blue circles are mRNAs directly linked to regulated lncRNAs, green circles are mRNAs also regulated, but not connected to lncRNAs described in our study. Note central nodes for NFκB and CREB1.
