Figure 1.

Proliferation pathways mediated by MYC and MYC cofactors. MYC drives proliferation through stimulating cell growth (biomass accumulation) and cell-cycle entry from quiescence while inhibiting cell-cycle inhibitors for cell-cycle progression. Cofactors (in red) control the indicated proliferative pathways that can be opposed by other factors, such as TGF-β and MXD/MAX. Repression of cell-cycle inhibitors by MYC, which appears to be sufficient to drive cell-cycle progression, may be mediated by several possible mechanisms, including the recruitment of repressive complexes containing MIZ-1 or SP1 and/or indirect repression caused by EZH2 induction.