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Schematic time line following primary pulmonary infection with M. tuberculosis. Data of time line of tuberculosis is adapted from Marais et al. (2005a), first described by Wallgren (1948). 0, Incubation; I, tuberculin skin test conversion; II, Ghon focus and/or disseminated (miliary) disease; III, lymph node disease (<5 yr of age)/pleural effusion (>5 yr of age); IV, adult-type disease (>10 yr of age).
