Table 1.

Optimization of the Suzuki coupling of compound 2.

Compounds	Pd-source	Ligand	Base	Solvents	Yields (%)
3	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	4
3	Pd(OAc)2	XPhosa	K3PO4	THF/MeOH	44
4	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	12
4	Pd(OAc)2	Xphosa	K3PO4	THF/MeOH	53
5	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	8
5	Pd(OAc)2	Xphosa	K3PO4	THF/MeOH	61
6	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	4
6	Pd(OAc)2	XPhosa	K3PO4	THF/MeOH	41
7	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	9
7	Pd(OAc)2	Xphosa	K3PO4	THF/MeOH	55
8	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	4
8	Pd(OAc)2	XPhosa	K3PO4	THF/MeOH	42
9	Pd[P(Ph)3]4	–	K2CO3	THF/MeOH	7
9	Pd(OAc)2	Xphosa	K3PO4	THF/MeOH	57

^aXPhos: (2-biphenylyl)-dicyclohexyl-phosphine.