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Cytotoxicity of noscapine derivatives for human peripheral blood lymphocytes (PBL).
| Compound | IC50 (µM)a | |
|---|---|---|
| PBLresting b | PBLPHA c | |
| 2 | >200 | 92.2 ± 13.8 |
| 3 | >200 | >200 |
| 4 | >200 | 54.9 ± 7.6 |
| 5 | >200 | >200 |
| 6 | >200 | 42.4 ± 5.0 |
| 7 | >200 | >200 |
| 8 | >200 | >200 |
| 9 | >200 | >200 |
Compound concentration required to reduce cell growth by 50%.
PBL not stimulated with PHA.
PBL stimulated with PHA. Values are the mean ± SEM for three separate experiments.
