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. Author manuscript; available in PMC: 2014 Aug 25.
Published in final edited form as: J Immunol. 2008 Oct 15;181(8):5451–5461. doi: 10.4049/jimmunol.181.8.5451

FIGURE 2.

FIGURE 2

The binding frame of CLIP2 for binding to DQ2 is determined to be PLLMQALPM. (A) The IC50 values of truncated and mutated versions of the CLIP2 peptide were measured. IC50 is the peptide concentration required to give 50% inhibition of the indicator peptide KPLLIIAEDVEGEY. The underlined residues P and M denote positions P1 and P9 in the DQ2 peptide binding frame. Dotted bars indicate IC50 values higher than 167 μM. Data are from one of at least three independent experiments. (B) Depiction of the CLIP1 and CLIP2 binding frames.