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. Author manuscript; available in PMC: 2014 Aug 25.
Published in final edited form as: Cancer Gene Ther. 2011 Aug 26;18(12):850–858. doi: 10.1038/cgt.2011.54

Figure 6. Effect of ODN1826 (ODN) on the tumor microenvironment in wild-type (WT) and CEA-Tg mice.

Figure 6

MC38 tumor cells were implanted s.c. on day 1 into C57Bl/6 WT and CEA-Tg mice. Groups of mice were treated with ODN on days 15 and 17 and spleens harvested on day 17. (A) The relative levels of immunoregulatory cytokines/factors were determined by QRT-PCR at baseline. Data represent means ± SD, n = 4 mice per group. (b) Phenotypes of infiltrating cells were assessed by immunohistochemistry. Data represent means ± SD, n = 4 mice per group. * = P < 0.05, WT versus CEA-Tg; ** P < 0.05, ODN versus no treatment.