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. 2014 Aug 25;9(8):e104934. doi: 10.1371/journal.pone.0104934

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© 2014 Shang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The top ranked candidate metabolites of AD are showed in the KEGG metabolic network. The gray, blue and red nodes represent candidate metabolites, known metabolites (seed nodes) and top 1% ranked candidates, respectively. The black boxes represent 6 candidates which ranked in top 10 and their connected functional pathway nodes in both metabolic networks. The right large box shows the pathway of “Valine, leucine and isoleucine degradation” which includes the metabolite (S)-Methylmalonate semialdehyde (arrow pointed).