Table 1. The AUC value of 16 disease classes.

Disease Class	AUC value
	KEGG without FPN	PROFANCY in KEGG	EHMN without FPN	PROFANCY in EHMN
Metabolic	0.935	0.957	0.92	0.936
Neurological	0.882	0.903	0.803	0.861
Cardiovascular	0.909	0.846	0.861	0.84
Endocrine	0.868	0.865	0.832	0.83
Immunological	0.832	0.961	0.856	0.909
Muscular	0.988	0.973	0.293	0.797
Psychiatric	0.831	0.873	0.706	0.85
Cancer	0.885	0.882	0.722	0.788
Connective tissue	0.859	0.838	0.794	0.793
Developmental	0.488	0.578	0.466	0.556
Gastrointestinal	0.788	0.821	0.774	0.948
Multiple	0.7	0.632	0.712	0.776
Respiratory	0.999	0.999	0.974	0.991
Renal	0.934	0.936	0.879	0.881
Nutritional	0.681	0.639	0.721	0.684
Hematological	0.343	0.425	0.809	0.612
All	0.88	0.895	0.824	0.871

FPN = functional pathway nodes.