Figure 3.
Pharmacokinetic profile of hGH in rat serum after hGH administration using microneedles. Five experimental groups were studied to assess different methods of hGH administration: (1) subcutaneous injection (●), (2) CMC microneedle patch (▲), (3) subcutaneous injection of reconstituted CMC microneedle patch after 15 months storage at ambient conditions (▾), (4) CMC/trehalose microneedle patch (◆), and (5) subcutaneous injection of reconstituted CMC/trehalose microneedle patch (▪). Data represent the average ± standard deviation, n=6 for all groups except Group 3 (n=3).