Table 1. Impact of hyperlipidemia on the characteristics of the mice.

	16-week-old mice	32-week-old mice	52-week-old mice
Wild-type
BW (g)	24.9±0.4 (12)	30.8±0.4 (8)	38.3±1 (14)
SBP (mmHg)	99±2 (12)	99±1 (8)	96±3 (14)
HR (beats/min)	652±6 (12)	655±10 (8)	683±13 (14)
T-Cho (mg/dl)	56±2 (11)	54±3 (8)	61±4 (14)
Apo E−/−
BW (g)	28.0±0.8 * (8)	30.6±0.7 (10)	33.9±0.7 ** (13)
SBP (mmHg)	102±2 (8)	99±2 (10)	97±2 (13)
HR (beats/min)	648±28 (8)	679±8 (10)	667±10 (13)
T-Cho (mg/dl)	687±81 *** (5)	707±70 *** (9)	702±55 *** (12)

Data are expressed as mean ± SEM (Parentheses indicate the number examined).

*P<0.05, **P<0.001, ***P<0.0001 vs. wild-type.

BW, body weight; SBP, systolic blood pressure; HR, heart rate; T-Cho, total cholesterol.

Apo E^−/−, apo E knockout mice.