Figure 5. Tle4 null mice develop splenic atrophy with abnormal splenic architecture.

(a) At three weeks of age there is marked splenic atrophy and decreased cellularity especially of the major B-cell (B220+) compartment. (b) H&E staining of the spleen reveals an absence of splenic follicles (dashed oval) in two week old Tle4 null mice (KO). (n = 3–4 per genotype; mean +/−SEM; *: P<.05).