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. Author manuscript; available in PMC: 2014 Aug 25.
Published in final edited form as: Lab Chip. 2011 Jun 28;11(16):2701–2710. doi: 10.1039/c1lc20105k

Fig. 1. iMAP array.

Fig. 1

(A) consists of 64 processing modules (B) that can perform 64 independent simultaneous integrated assays. The integrated function of each processing module can be flexibly selected by the user and depends entirely on the sequence and timing of the fluid inputs. The basic steps required for three different cell based assays are illustrated (A). This versatility allows the user to combine cell stimulation and gene and protein expression analysis on a single microfluidic platform. For statistical replication purposes each module consists of 8 parallel and equally distributed (C) processing chambers that contain a central trench structure (D). Each processing chamber can execute any sequence laboratory unit operations (E), gravity driven flow (E1), cell capture (E2) and reagent loading and mixing (E3).