Table 3. Association results of the two SNPs with risk of S. japonicum infection in the discovery, replicative and combined studies.

SNPs	Discovery study				Replicative study				Combined study
	Cases	Controls	OR	P	Cases	Controls	OR	P	Cases	Controls	OR	P
	(%)	(%)	(95% CI)		(%)	(%)	(95% CI)		(%)	(%)	(95% CI)
rs391957
AA	30	27	1.13	0.508	24	71	0.83	0.559	54	98	0.97	0.837
	(5.71)	(5.08)	(0.66–1.94)		(4.91)	(5.69)	(0.52–1.38)		(5.33)	(5.51)	(0.69–1.36)
AG	167	230	0.69	0.003	210	490	1.12	0.187	377	720	0.87	0.087
	(31.81)	(43.23)	(0.51–0.86)		(42.94)	(39.29)	(0.92–1.43)		(37.18)	(40.47)	(0.74–1.02)
GG	328	275	1.59	0.001	255	686	0.93	0.303	583	961	1.15	0.076
	(62.48)	(51.69)	(1.25–2.03)		(52.15)	(55.01)	(0.75–1.14)		(57.50)	(54.02)	(0.99–1.35)
rs10118570
GG	15	36	0.35	9.616×10−4	14	87	0.37	9.581×10−4	29	123	0.45	7.902×10−6
	(2.86)	(6.77)	(0.18–0.69)		(2.86)	(6.98)	(0.20–0.69)		(2.86)	(6.91)	(0.29–0.66)
AG	150	179	0.82	0.086	206	449	1.27	0.039	356	628	0.93	0.808
	(28.57)	(33.65)	(0.62–1.05)		(42.13)	(36.01)	(1.04–1.55)		(35.11)	(35.30)	(0.80–1.13)
AA	360	317	1.36	3.553×10−3	269	711	0.97	0.496	629	1028	1.21	0.025
	(68.57)	(59.59)	(1.10–1.84)		(55.01)	(57.02)	(0.77–1.18)		(62.03)	(57.79)	(1.03–1.44)

Adjusted for age, gender, smoking and drinking.

P<1.163×10⁻³ means significant value by Bonferroni correction based on the total number of markers genotyped.