Figure 2. Unsupervised hierarchical clustering of Pyrosequencing data for genes that were found methylated in SI-NETs. MetI values of 0–100% were converted to a range of 0 to 1 and subjected to Euclidean hierarchical clustering. The three tumor clusters are indicated as I, II and III. Gray indicates lack of data. Previously published¹⁵ data for copy number loss determined by qPCR for loci representing 11q (SDHD), 16q (CDH1), 18p (EMILIN2) and 18q (CDH19) in case 1–32 are indicated to the right for comparison.