Figure 3. Principal component analysis (PCA) and heatmap visualization of metastable DMPs (A) PCA of SNP-associated (top panel) vs. non SNP-associated metastable DMP. The between-sample variance relative to the between-class variance is higher for SNP-associated probes. Pooled samples are labeled alphabetically. Cases are shown in red, controls in blue. (B) Cluster heatmap analysis of 92 non-SNP metastable DMP. Rows represent probes and columns represent samples. Cells are colored according to level of methylation (Blue = low methylation, yellow = high methylation, scale denotes row standard deviations). Sample annotation is indicated below the dendrogram.