Table 2.

Top SNPs Showing an Interaction with Smoking on Carotid Plaque Area In Discovery Sample

SNP	Chr	BP	Minor/Major Allele	Discovery			Replication			Combined			Nearby Gene
				MAF	Beta ± SE	P	MAF	Beta ± SE	P	MAF	Beta±SE	P
rs6700792	1	231170013	C/T	0.43	0.41±0.09	1.0E-05	0.46	0.22±0.15	0.149	0.44	0.36±0.08	6.9E-06	FAM89A
rs4074493	1	231172281	T/C	0.43	0.42±0.09	7.9E-06	0.45	0.20±0.15	0.182	0.43	0.36±0.08	6.6E-06	FAM89A
rs10205487	2	70151471	A/G	0.45	0.43±0.10	7.7E-06	0.45	0.29±0.14	0.041	0.45	0.38±0.08	2.3E-06	MXD1
rs2894889	6	100161940	T/A	0.41	−0.41±0.09	7.4E-06	0.46	−0.05±0.14	0.736	0.42	−0.28±0.08	2.2E-04	PRDM13||MCHR2
rs7001413	8	75010233	T/G	0.07	−0.74±0.17	1.1E-05	0.08	−0.48±0.24	0.046	0.08	−0.63±0.14	5.0E-06	LY96||JPH1
rs7901717	10	113593918	T/C	0.38	−0.48±0.11	7.0E-06	0.35	−0.07±0.15	0.649	0.37	−0.34±0.09	1.1E-04	GPAM
rs215986	12	2709880	T/C	0.21	0.54±0.11	1.0E-06	0.26	0.04±0.19	0.819	0.22	0.39±0.09	4.2E-05	CACNA1C
rs216008	12	2721137	T/C	0.20	0.53±0.11	9.8E-07	0.25	0.06±0.19	0.761	0.22	0.40±0.09	2.7E-05	CACNA1C
rs17087142	13	71014985	A/G	0.08	−0.64±0.14	7.7E-06	0.09	0.17±0.27	0.517	0.09	−0.46±0.13	3.3E-04	ATXN8OS||DACH1
rs7182209	15	46132501	C/T	0.12	−0.58±0.13	1.0E-05	0.11	−0.27±0.22	0.224	0.11	−0.50±0.11	9.2E-06	SQRDL||SEMA6D
rs16945167	15	62790756	T/A	0.07	−0.80±0.17	2.1E-06	0.05	0.35±0.36	0.337	0.07	−0.57±0.15	2.0E-04	MGC15885