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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Chem Soc Rev. 2014 Oct 7;43(19):6750–6764. doi: 10.1039/c3cs60459d

Figure 5.

Figure 5

Conventional β-sheet channel vs. β-barrel designs. (A) The conventional β-sheet channel has the β-strands that orient parallel to the membrane normal, (B) while the β-strands that orient obliquely to the membrane normal generate β-barrel structure. Above examples are shown for the p3 (Aβ17-42) channel and barrel. Other examples of the β-sheet channel and barrel formed by the U-shaped K3 (a fragment of β2-microglobulin) peptide and by the PG-1 and MAX β-hairpins. (C) The 24-mer channel embedded in the DOPC bilayer in stereo view.75 (D) The 8-mer PG-1 channels with the antiparallel and parallel β-strand arrangements.108 (E) The 10-mer antiparallel MAX channels and barrels in the NCCN and NCNC packing modes (from Gupta et al., 2013,110 reprinted with permission).