. Author manuscript; available in PMC: 2015 Oct 7.

Published in final edited form as: Chem Soc Rev. 2014 Oct 7;43(19):6750–6764. doi: 10.1039/c3cs60459d

Table 4.

Structural features of the p3 (Aβ_17-42) F19P mutant channel, the full-length (Aβ_1-42) F19P and F20C barrels, and the Osaka mutant (ΔE22) barrels with an absence of Glu22 in various lipid bilayers.

Aβ mutant channel/barrel	Outer diameter (nm)	Pore diameter (nm)	Pore status	Number of peptides	Embedded lipid	Reference
p3-F19P channel	~6.4	~0.9	clogged up	16	DOPC	36
F19P barrel (Conformer 1)	~7.7	~1.5	clogged up	18	DOPS/POPE=1:2	78,104
F19P barrel (Conformer 2)	~7.6	~1.7	collapsed	18	DOPS/POPE=1:2	78,104
F20C barrel (Conformer 1)	~7.9	~1.7	opened	18	DOPS/POPE=1:2	78,104
F20C barrel (Conformer 2)	~8.1	~1.7	partially collapsed	18	DOPS/POPE=1:2	78,104
ΔE22 barrel (Conformer 1)	~7.9	~2.1	opened	18	DOPC	106
ΔE22 barrel (Conformer 2)	~7.6	~1.5	reduced	18	DOPC	106